在电动力学原子化粉颗粒中进行溶剂交换,随后进行冷化以提高血液凝固性能
Pradyumna Kumar Sasmal1, S Ganguly2
1Indian Institute of Technology Kharagpur, Kharagpur, Kharagpur, WB, 721302, INDIA.
Biomedical materials (Bristol, England)
|January 28, 2026
概括
新的基于粉的微粒物显著加速血液凝固并减少血液流失,性能优于商业血静止剂. 这些多孔颗粒也表现出抗菌性质,并在一周内降解.
科学领域:
- 生物材料科学 生物材料科学
- 血液静止研究 血液静止研究
- 伤口愈合技术 伤口愈合技术
背景情况:
- 开发有效的止血剂对于在创伤和手术中控制出血至关重要.
- 目前的血静止剂在有效性,生物相容性和抗菌活性方面存在局限性.
- 基于粉的材料由于其生物相容性和可调节性特性,具有创造新型血液静止微粒的潜力.
研究的目的:
- 开发和描述用于静血应用的新型电动力学分离性粉微粒.
- 为了评估这些粉微粒的静血,抗微生物和降解特性.
- 为了比较开发的微粒与商业上可用的血液控制器的性能.
主要方法:
- 粉悬浮被交叉连接,接受溶剂交换,并冷化以创建多孔的微粒.
- 微粒被装满了tranexamic acid (TA) 以加强凝块的稳定性.
- 进行了体外凝血试验,血栓结石学,老鼠损伤模型,抗菌试验和体外降解研究.
主要成果:
- 多孔粉微粒表现出高表面积 (13.4 m2/g) 和吸水能力 (3.26x干重).
- 试验室凝血时间从155秒减少到64秒;与商业血静止剂相比,大鼠模型显示凝血时间小于1分钟,血液损失减少.
- 微粒物显示出对S. aureus和E. coli的优越抗菌活性,并在PBS中在37°C下降解了90%在6天内.
结论:
- 电动力学分离粉微粒是有效的静血剂,具有快速凝结和减少血液损失.
- 开发的微粒具有显著的抗微生物特性和有利于伤口愈合的降解动力学.
- 这些基于粉的微粒物代表了当前用于伤口管理的商业血静止剂的有希望的替代品.
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