对多环芳的产前暴露与新生儿出生结果之间的关联:横截面研究
Lin Tao1, Shimin Xiong2, Dengqing Liao2
1Centre for Disease Control and Prevention, Huaxi District, Guiyang, Guizhou 550025, China; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China; Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes, Zunyi, Guizhou 563000, China.
Ecotoxicology and environmental safety
|January 28, 2026
概括
产前暴露于多环芳 (PAH) 代谢物会影响分娩结果,在怀孕晚期的度更高. 这些暴露显示了剂量-反应关系和对新生儿发育的性别特异性影响.
科学领域:
- 环境健康科学 环境健康科学
- 围产期流行病学 围产期流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 多环芳 (PAHs) 是环境污染物,可能对怀孕产生不良影响.
- 了解PAH代谢物暴露在妊娠阶段的影响对于母婴健康至关重要.
- 以前的研究表明,PAH暴露和不良出生结果之间存在潜在联系,但妊娠期和性别特异性影响需要进一步阐明.
研究的目的:
- 为了描述不同妊娠阶段的孕妇在尿液中的多环芳 (PAH) 代谢物度.
- 研究这些PAH代谢物度与新生儿出生结果之间的关联,考虑妊娠时间和性别.
- 探索PAH代谢物混合物对胎儿发育的剂量反应关系和潜在的性别特异性影响.
主要方法:
- 一项包括3689名孕妇 (年龄在20-45岁) 的队列研究,采用了怀孕早期和晚期收集的尿样.
- 使用回归分析,限制立方线 (RCS) 模型和贝叶斯核机回归 (BKMR) 来进行混合物分析,量化尿中PAH代谢物.
- 进行了非分层和分层的新生儿性别统计分析,以确定特定性别的关联和剂量反应模式.
主要成果:
- 尿中PAH代谢物度在怀孕晚期明显高于怀孕早期.
- 特定的PAH代谢物 (例如4-基,1-基) 与出生体重,长度和均值有关,具有显著的性别特异性影响.
- 对于跨妊娠阶段的PAH代谢物混合物,观察到非线性暴露-反应关系和明显的性别特异性模式.
结论:
- 产前暴露于PAH代谢物与新生儿出生结果有关,影响因妊娠阶段和婴儿性别而异.
- 该研究突出了可辨认的剂量反应关系和性别特异性的怀孕期间对PAH暴露的脆弱性.
- 研究结果强调了在评估环境污染物对胎儿发育的影响时考虑妊娠时间和性别的重要性.
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