免疫疗法耐药性和药物查中的瘤免疫器官
Minghui Zhang1, Lijun Li2, Haihong Pu2
1Clinical Research Center (CRC), Chongqing University Three Gorges Hospital, Chongqing University, Chongqing 404100, China; School of Medicine Chongqing University, Chongqing University, Chongqing 400030, China.
概括
瘤免疫有机体,包括免疫和 stromal 细胞,正在通过模仿瘤微环境,推进癌症研究. 这些模型对了解免疫疗法耐药性和开发个性化癌症治疗有希望.
科学领域:
- 癌症研究 癌症研究
- 免疫治疗是一种免疫疗法.
- 有机物技术 有机物技术
背景情况:
- 传统的瘤器官缺乏免疫和层细胞,限制了它们模拟瘤微环境 (TME) 的能力.
- 这种缺陷阻碍了对TME内部复杂相互作用和对免疫治疗的反应的研究.
研究的目的:
- 审查当前和新兴的瘤免疫有机体模型,这些模型包含免疫和 stromal 分区.
- 探索它们在研究免疫疗法反应和抵抗机制方面的潜力.
主要方法:
- 同培养瘤有机体与树皮和免疫细胞.
- 使用微流体和空气液体接口 (ALI) 培养技术来保存TME.
主要成果:
- 瘤免疫有机体成功地回顾了TME和免疫治疗效应.
- 这些模型可用于研究瘤内在和外在免疫疗法耐药性机制.
结论:
- 瘤免疫器官是预测免疫疗法的有效性和选新药的宝贵工具.
- 对于个性化癌症免疫疗法的更广泛的临床应用,有机体培养技术的进一步进步是必要的.
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