相关实验视频
Updated: Jan 30, 2026

11:37
In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells
Published on: February 18, 2015
14.2K
针对癌症干细胞作为最具攻击性和瘤发起细胞
Maryam Sadri1, Zahra Shafaghat1, Mona Roozbehani2
1Department of Immunology, Iran University of Medical Sciences, Tehran, Iran.
Translational oncology
|January 28, 2026
概括
癌症干细胞 (CSCs) 驱动瘤生长和抵抗. 用组合疗法 (包括免疫疗法) 向这些攻击性细胞对于彻底消灭癌症和预防复发至关重要.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 干细胞研究 干细胞研究
背景情况:
- 癌症干细胞 (CSCs) 是瘤细胞的一个小,积极的亚群.
- CSCs具有自我更新和分化能力,驱动瘤的开始,进展和转移.
- 这些细胞有助于多药性耐药性 (MDR),放射性耐药性和癌症复发.
研究的目的:
- 审查针对癌症干细胞 (CSCs) 的现有策略.
- 突出CSCs在癌症持久性和治疗失败中的重要性.
- 探索用于彻底根除癌症的组合疗法.
主要方法:
- 对当前CSC目标化策略的文献综述.
- 分析CSC特征及其在恶性瘤中的作用.
- 综合免疫疗法和细胞毒剂组合疗法的评估.
主要成果:
- 瘤中枢细胞是瘤生长,转移和对常规疗法的耐药性的关键驱动因素.
- 骨髓癌症与癌症复发和最小残留疾病有关.
- 组合疗法在同时消除CSC和非CSC方面表现有前途.
结论:
- 向癌症干细胞对于实现完全瘤根除至关重要.
- 将免疫疗法与细胞毒疗法相结合,提供了一种有前途的策略,以克服CSC介导的耐药性并改善患者的治疗结果.
- 对CSC向治疗的进一步研究是有必要的,以提高癌症治疗的疗效.
相关概念视频
Cancer Stem Cells and Tumor Maintenance
6.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K
Aggression
30.4K
Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
30.4K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K
Adult Stem Cells
33.8K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.8K
Embryonic Stem Cells
32.4K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.4K
Induced Pluripotent Stem Cells
28.0K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.0K

