孕期疟疾在前线:一个微妙的平衡
Vivin Kokuhennadige1, Elizabeth Aitken2, Stephen Rogerson3
1Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.
Current opinion in immunology
|January 28, 2026
概括
孕期疟疾伤害母亲和婴儿,特别是在非洲. 针对早期感染和开发疫苗的干预措施对于改善母亲和婴儿健康结果至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 怀孕期间的疟疾对孕产妇,胎儿和婴儿健康构成重大风险,非洲的疟疾病例显著增加.
- 胎盘等离子杆菌感染导致炎症,孕产妇发病率和不良分娩结果.
- 产前疟疾感染有新兴证据将其与婴儿免疫和神经认知发育受损联系起来.
研究的目的:
- 审查最近关于怀孕期间疟疾的发现,包括病变发生,免疫力和后代的结果.
- 评估当前针对怀孕期间疟疾的干预措施的有效性.
- 确定控制孕妇疟疾的最佳策略.
主要方法:
- 关于最近关于怀孕期间疟疾的发现的文献综述.
- 对病变发生,宿主免疫力和后代发育的分析.
- 评估干预的有效性,包括间歇性预防治疗和药物组合.
主要成果:
- 胎盘疟疾会导致不良的分娩结果,在连续怀孕中形成保护.
- 尽管对寄生虫有耐药性,但硫氨酸-胺胺 (SP) 改善了出生体重.
- 狄氏甲美西宁-皮佩拉奎因对寄生病有疗效,但不能单独或与SP一起改善分娩结果.
结论:
- 针对第一季度感染的干预措施至关重要.
- 开发用于原生动物主要免疫力的疫苗是一个有前途的战略.
- 在怀孕期间控制疟疾需要多方面的方法来应对早期感染并增强宿主防御能力.
相关概念视频
Balancing Redox Equations
61.9K
Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
61.9K
Equilibrium and Balance
6.5K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
6.5K
Energy Balance
1.2K
The human body gets energy from the three macronutrients: carbohydrates, proteins, and fats. Energy is released when the chemical bonds in the organic compounds present in the food are broken down. The energy content of food is measured in kilocalories (kcal), defined as the amount of heat required to raise the temperature of one kilogram of water by one degree Celsius. This value is determined by measuring the temperature change of the water surrounding a calorimeter after the complete...
1.2K
Respiratory Regulation of Acid-Base Balance
1.7K
Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2 and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
1.7K
Disorder of Water Balance
2.5K
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
2.5K
Acid-Base Balance
2.5K
The human body maintains a narrow pH range regulated through acid-base balance. This balance is crucial as changes in the hydrogen ion concentration can disrupt cell membrane stability, alter protein structures, and change enzyme activities. The normal pH of arterial blood is 7.4, venous blood and interstitial fluid is 7.35, and intracellular fluid averages 7.0.
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
2.5K


