使用CPP/氨酸修饰的半孔化纳米颗粒口服输送利拉格卢提德:一种病毒启发的肠道吸收策略
Narges Shams1, Mehdi Esfandyari-Manesh2, Mohammad Sharifzadeh3
1Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Biomaterials advances
|January 28, 2026
概括
一种新型模仿病毒的纳米载体通过克服胃肠道障碍来增强口服类药物输送. 这种空洞的中孔氧化纳米粒子系统改善了糖尿病老鼠的利拉格卢提德吸收和疗效,为注射提供了一个有前途的非侵入性替代品.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 口服类药物递送面临重大挑战,包括酶降解和胃肠道吸收不良.
- 可注射配方可以改善患者的服药,但具有侵入性和不那么方便.
- 开发非侵入性口服输送系统,用于类药物,如利拉格卢提德,对于治疗进步至关重要.
研究的目的:
- 开发一种模仿病毒的纳米载体,以增强利拉格卢提德的口服输送.
- 通过细胞透 (CPP) 和酸 (HA) 功能化空洞的半孔性二氧化纳米粒子 (HMSN),以改善运输和准.
- 在糖尿病老鼠模型中评估口服纳米载体系统的疗效和安全性.
主要方法:
- 通过共凝结合成空洞的半孔性二氧化纳米粒子 (HMSN).
- 使用 KLPVM (CPP) 和 Hyaluronic 酸 (HA) 的 HMSN 的功能.
- 利拉格卢提德的封装,体外释放研究,细胞吸收,体外透性,以及糖尿病大鼠体内药学动力学评估.
主要成果:
- 高封装效率 (96.16%) 和药物负载 (19.23%) 的利拉格卢提德.
- 响应pH的释放特征:在酸性条件下释放低,在肠道pH下持续释放.
- 增强细胞吸收 (98.1%) 和显著改善肠道透性 (97.6%).
- 在糖尿病大鼠中,口服添加利拉格卢提德的HMSN-CPP@HA可降低禁食血糖水平50.98%和体重14.6%,与皮下注射相比较.
结论:
- 模仿病毒的HMSN-CPP@HA纳米载体在胃肠道过境期间有效地保护利拉古.
- 该系统显示了肠道吸收的增强,并保持了药物的生物活性.
- 这个平台代表了对非侵入性口服输送治疗药物的有希望的战略.
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