聚乙烯纳米塑料和病原体可塑性:在沙门氏菌中存在毒性威胁或耐受性压力因素
Jayita De1, Goutam Banerjee1, Edwin Valenzuela De Leon1
1Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.
Journal of hazardous materials
|January 28, 2026
概括
聚烯纳米塑料 (PS-NPs) 改变了沙门氏菌的毒性和生存率. 较高的PS-NP度会破坏细菌膜,增加生物膜的形成,影响食品安全.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 食品安全 食品安全
背景情况:
- 聚乙烯纳米塑料 (PS-NP) 是新兴的环境污染物.
- 它们对微生物生态和食品安全构成风险.
- 沙门氏菌 (Salmonella enterica) 是一种重要的食物传播病原体.
研究的目的:
- 研究PS-NP对沙门氏菌肠道活力,膜完整性和应激反应的影响.
- 分析与毒性,粘附性和抗菌素耐药性相关的基因表达变化.
- 评估PS-NP对生物膜形成的影响.
主要方法:
- 沙门氏体暴露于不同度的PS-NP (2.5-100 mg/L).
- 评估细菌活力,膜完整性和氧化应激.
- 基因表达分析 (qPCR).
- 生物膜量化 (外聚糖类测量,共聚焦显微镜).
主要成果:
- PS-NPs影响了细菌活力,膜完整性和氧化应激,更高度会导致脂质过氧化.
- 观察到压力,生物膜,毒性和粘附基因的早期上调.
- 中等到高的PS-NP暴露增加了生物膜的形成.
- 长时间/高剂量暴露降低了排泄系统,定数感知调节器和抗菌素耐药性基因的调节.
- 特定基因的短暂激活表明了潜在的交叉抵抗机制.
结论:
- PS-NP 作为环境压力因素,改变沙门氏菌的毒性和生存策略.
- 这些发现对塑料污染环境和食品加工中的微生物行为有影响.
- 迫切需要在公共卫生和抗菌素耐药性背景下重新评估纳米塑料暴露.
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