牙周炎和口腔癌的时空共发生模式:全球风险因素和网络分析
Yu Xia1, Jukun Song2
1Department of Oral Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
International dental journal
|January 28, 2026
概括
牙周病在全球范围内比口腔癌更为常见,与吸烟等重叠的危险因素相匹配. 定制的预防策略对于减少这两种疾病的负担至关重要.
科学领域:
- 流行病学 流行病学
- 全球健康 全球健康
- 口腔健康 口腔健康
背景情况:
- 牙周病和口腔癌具有共同的风险因素,并且可能表现出同时发生的模式.
- 了解这些模式对于公共卫生干预至关重要.
研究的目的:
- 描述牙周病和口腔癌的全球共发生模式.
- 使用2021年全球疾病负担 (GBD) 数据识别共享和特定疾病的风险因素.
主要方法:
- 分析了204个国家的成年人发病率 (≥25岁) 和68个风险因素 (1990-2021年).
- 根据发病率四分位数的国家分类 (一致性,牙周主导,口腔癌主导).
- 应用沙普利增量解释 (SHAP) 建模,负二项式回归,网络分析和格兰杰因果关系测试.
主要成果:
- 在2021年,牙周炎发病率 (1740.92/100,000) 远远超过了口腔癌发病率 (8.97/100,000).
- 南亚/东南亚高负担国家的显著地理聚类.
- 确定了关键风险因素:口腔癌的烟草,铁缺乏和高酒精使用;高静脉血压,暴露和牙周炎的加工肉类.
结论:
- 牙周病和口腔癌显示出不同的,但重叠的全球分布.
- 共同暴露,如烟草和污染物,有助于共同疾病.
- 针对可修改风险的综合初级保健可以降低整体疾病负担.
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