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台湾年轻人的长度PFAS暴露和甲状腺功能轨迹:为期10年的前性队列研究
Chien-Yu Lin1, Hui-Ling Lee2, Ta-Chen Su3
1Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan.
Environment international
|January 28, 2026
概括
和多基物质 (PFAS) 暴露与甲状腺功能障碍有关. 这项研究发现,在年轻成年人中,PFAS与较低的甲状腺刺激激素 (TSH) 和较高的自由甲状腺素 (自由T4) 相关,超过10年.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 越来越多的证据将每和多醇基物质 (PFAS) 与甲状腺功能障碍联系起来.
- 有限的纵向数据存在于从青春期到早期成年期对甲状腺功能的PFAS影响.
研究的目的:
- 在青少年和年轻人中研究PFAS暴露与甲状腺功能 (TSH和自由T4) 之间的纵向关联.
- 检查PFAS暴露与甲状腺疾病发病率之间的关系.
主要方法:
- 对来自YOTA的495名参与者 (年龄在12-30岁) 的分析,随访时间为9-12年.
- 在基线和随访时测量血PFAS,血清TSH和自由T4.
- 使用多变量回归模型来评估PFAS暴露指数与甲状腺激素之间的关联,以及发生甲状腺疾病的Cox模型.
主要成果:
- 较高的PFAS基线暴露和随着时间的推移增加的PFAS水平与较低的TSH有关.
- 随着时间的推移,增加的PFAS暴露与更高的自由T4水平有关,特别是与线性PFOA和PFDoA有关.
- 每年PFAS暴露量的较大增加与甲状腺功能低下和甲状腺结节的风险降低有关.
结论:
- 从青春期到青春期持续暴露于PFAS与甲状腺轴扰动有关,由较低的TSH和较高的自由T4表明.
- 这些发现突出了对PFAS对甲状腺健康的影响敏感的发育窗口.
- 支持长期生物监测和加强对PFAS污染的监管行动的需要.
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