与自闭症和异常神经发育相关的眼睛表型:电子健康记录的见解
Antoinette S DiCriscio1, Julie-Anne Little2, Vanessa Troiani1
1Geisinger Health System, Developmental Medicine, Lewisburg, PA, United States.
Vision research
|January 28, 2026
概括
患有自闭症谱系障碍 (ASD) 的儿童表现出较高的视力障碍和眼动障碍. 这项研究使用电子健康记录在患有自闭症和其他神经发育差异的儿科患者中识别这些眼部疾病.
科学领域:
- 眼科医生 眼科 眼科
- 神经发育障碍 神经发育障碍
- 儿科健康 儿科健康
背景情况:
- 非典型的视觉感知在自闭症谱系障碍 (ASD) 中很常见,但使用常规视觉指标对眼部疾病的研究不足.
- 电子健康记录 (EHR) 提供了一个宝贵的资源,用于调查大儿科患者群体的视力表型.
研究的目的:
- 使用EHR数据,对患有ASD和其他神经发育诊断的儿童的眼病状况进行表征.
- 为了比较诊断组和匹配的对照组之间的特定眼部疾病类别的患病率.
主要方法:
- 一种人口健康方法,分析了来自7518名儿科患者的EHR代码.
- 眼部疾病分为5个类别:视力障碍,折射/适应性障碍,眼动/眼障碍,视网膜/眼部疾病,光敏感性/瞳孔反应.
- 在ASD,智力障碍 (ID),语言障碍 (LD) 和匹配的对照组 (MC) 之间比较眼部疾病率.
主要成果:
- 在诊断组中,与匹配的对照组相比,观察到眼部疾病的发病率增加.
- 具体来说,在视力障碍 (1类) 和眼动/眼障碍 (3类) 中发现了更高的患病率.
结论:
- 电子健康记录数据提供了一种可扩展的方法来识别和理解ASD和其他神经发育差异的儿童的视觉表型.
- 这种方法可以提高我们对眼睛异常的理解,并为这些人群提供临床护理信息.
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