相关实验视频
Updated: Jan 30, 2026

09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
3.5K
味道分子通过肠-大脑轴调节食欲:一个新兴的视角
Qinfei Ke1, Yongkang Zheng1, Chi-Tang Ho2
1Collaborative Innovation Center of Fragrance Flavour and Cosmetics, School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China.
Food chemistry
|January 28, 2026
概括
生物活性味道分子通过肠-大脑轴调节食欲和新陈代谢. 这篇评论综合了它们对肠道微生物,腹信号和神经递质对功能性食物发展的影响.
科学领域:
- 营养神经科学 营养神经科学
- 微生物组研究 微生物组研究
- 代谢调节 代谢调节 代谢调节
背景情况:
- 生物活性味道分子影响食欲和能量代谢.
- 它们的复杂机制涉及肠-大脑轴,但缺乏综合理解.
- 现有的研究往往侧重于单个组成部分,限制了整体观点.
研究的目的:
- 合成生物活性风味分子对食欲和能量代谢的综合机制.
- 巩固涉及肠道微生物群,腹信号和神经网络的调节途径.
- 突出这些分子在功能性食品开发中的潜力.
主要方法:
- 对生物活性风味分子的现有文献进行系统审查.
- 分析包括微生物群调节,受体向和神经递质调节在内的途径.
- 在微生物,内分泌和神经系统之间整合发现.
主要成果:
- 确定了三个核心调节途径:微生物群增强,受体激活和神经递质调节.
- 证明了像eugenol, cinnamaldehyde和capsaicin这样的分子的协同作用.
- 强调了短链脂肪酸 (SCFA) 和神经递质 (GABA,5-HT,多巴胺) 的作用.
结论:
- 生物活性风味分子作为多功能肠-大脑调节器.
- 它们的协同作用提供了针对肠道微生物群的新策略.
- 这些发现支持开发功能性食物来控制食欲和代谢.
相关概念视频
Negative Regulator Molecules
38.5K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.5K
Positive Regulator Molecules
136.1K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
136.1K
Positive Regulator Molecules
6.9K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
6.9K
Hypothalamic-Pituitary Axis
66.0K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.0K
Emerging Adulthood
676
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
676
GTPases and their Regulation
9.8K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒ small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
Large G-proteins,...
9.8K

