来自的免疫调节剂:机械洞察力,奥米克集成,人工智能创新和精密免疫治疗中的临床应用
Hua Zhang1, Beng Fye Lau2, Chin Siang Kue3
1School of Graduate Studies, Management and Science University, University Drive, Off Persiaran Olahraga, Section 13, 40100 Shah Alam, Selangor, Malaysia; Institute of Basic Medicine, North Sichuan Medical College, 637100, Nanchong, Sichuan, China.
International immunopharmacology
|January 28, 2026
概括
含有调节免疫系统的生物活性化合物,为新的免疫疗法提供了潜力. 像奥米克和人工智能这样的先进技术可以优化它们在治疗癌症和自身免疫性疾病等疾病中的使用.
科学领域:
- 菌类学 菌类学是指菌类学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 含有多种生物活性化合物,具有显著的免疫调节特性.
- 这些化合物与免疫细胞上的模式识别受体 (PRR) 相互作用,影响先天性和适应性免疫力.
- 来自的化合物在癌症,传染病和自身免疫性疾病中显示出有前途的治疗效果.
研究的目的:
- 综合审查来自的化合物的免疫调节机制.
- 探索omics技术和人工智能 (AI) 在推进基于的免疫疗法的潜力.
- 提出克服临床翻译和标准化方面的挑战的策略.
主要方法:
- 关于生物活性化合物及其免疫相互作用的科学文献的综述.
- 涉及多糖,真菌免疫调节蛋白 (FIPs),莱克,类和类的机制的分析.
- 讨论omics技术和人工智能用于路径和目标识别.
主要成果:
- 化合物调节细胞因子的产生,Th1/Th2平衡和调节T细胞功能.
- 这些化合物会影响巨细胞,树突细胞和自然杀手细胞.
- 治疗应用范围包括癌症免疫疗法,传染病管理和自身免疫调节.
结论:
- 衍生化合物对下一代免疫疗法具有前景.
- 整合omics和AI可以增强对这些化合物的理解和应用.
- 标准化方法对于临床转化和优化疗效至关重要.
相关概念视频
Application of Integration: Problem Solving
93
The process of breathing involves the periodic intake and expulsion of air, known as the respiratory cycle, which typically lasts about five seconds. Modeling the volume of air inhaled into the lungs as a function of time provides insight into both the dynamics and efficiency of pulmonary ventilation. This volume is determined by integrating the airflow rate over time, which captures the cumulative effect of air entering the lungs.Sinusoidal Model of AirflowAirflow during respiration is not...
93
Applications of Integration to Find Hydrostatic Pressure
66
Hydrostatic force is a fluid's total force at rest on a surface. For a horizontal surface submerged at a fixed depth, the pressure is constant and calculated as the product of fluid density, gravitational acceleration, and depth. In the case of a vertical dam wall submerged in water, this force is not evenly distributed due to the increasing pressure with depth. This variation arises from the cumulative weight of the water above each point. Integration is used to account for the continuous...
66
Applications of Integration to Find Centers of Mass
76
Rotational equilibrium provides a natural framework for defining the center of mass of a system. For a plank balanced on a pivot with two unequal masses, equilibrium is achieved when the net torque about the pivot is zero. Torque is defined as the product of a force and its perpendicular distance from the pivot. When the torques due to all forces cancel, the pivot coincides with the center of mass of the system.For a system composed of several discrete point masses, the center of mass lies at...
76
Applications of Integration to Find Blood Flow
47
Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...
47
Applications of Integration to Find Consumer Surplus
56
In microeconomics, consumer surplus represents the economic gain that consumers experience when they purchase a good or service for less than the highest price they are willing to pay. This surplus arises from the characteristics of the demand function, which links the quantity of a good to the price consumers are willing to pay. As the quantity of a good increases, the price that consumers are willing to pay for each additional unit typically decreases, resulting in a downward-sloping demand...
56
Clinical Applications of Epidermal Stem Cells
3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K


