慢性伤口管理的便携式持续局部氧气治疗的临床有效性和安全性:一项随机对照试验
Yulin Zhu1,2, Qixia Jiang2, Yingying Zhan3
1School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China.
International wound journal
|January 28, 2026
概括
局部氧气治疗 (TOT) 通过在28天内减少伤口大小和深度,显著加快慢性伤口愈合. 这种便携式治疗改善了伤床pH值,导致愈合时间更快,没有不良事件.
科学领域:
- 伤口愈合研究研究研究.
- 生物医学工程 生物医学工程
- 临床试验中的临床试验.
背景情况:
- 慢性伤口是一个重大的临床挑战.
- 局部氧气治疗 (TOT) 是有前途的,但需要严格的评估.
- 便携式持续扩散氧气 (CDO) 系统提供了一个潜在的输送方法.
研究的目的:
- 评估便携式TOT在慢性伤口治疗中的有效性和安全性.
- 将TOT与标准湿伤疗法 (MWT) 进行比较.
- 评估伤口愈合参数,包括面积,深度,pH值,愈合速度和时间.
主要方法:
- 一个双臂随机对照试验,涉及88名患者.
- 患者被分配到28天的TOT (n=44) 或MWT (n=44) 组.
- 随访时间延长至12周,并对未愈合的伤口进行持续的MWT.
主要成果:
- 在28日,TOT组的伤口面积和伤口深度显著减少 (p<0.05).
- 伤床pH值在14日和28日的TOT组较低.
- 虽然TOT的28天治愈率更高 (45.5%对11.4%,p<0.001),但12周的治愈率相似 (95.5%对90.9%).
- 在12周,TOT显著减少了13.5天的愈合时间 (p=0.004).
- 没有报告TOT相关的不良事件.
结论:
- 便携式局部氧气治疗 (TOT) 是有效和安全的治疗慢性伤口.
- TOT通过改善伤床pH值和减少伤口尺寸来加速伤口愈合.
- 这种疗法为改善慢性伤口管理提供了一种有希望的方法.
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