怀孕期间母亲的咖啡消费和儿童的青春期发展:一项队列研究
Julie Lyngsø1, Nis Brix2, Andreas Ernst3
1Department of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Allé 2, 8000 Aarhus, Denmark; Department of Obstetrics and Gynaecology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.
Reproductive toxicology (Elmsford, N.Y.)
|January 28, 2026
概括
怀孕期间母亲喝咖啡可能会影响女儿的青春期时间. 高咖啡摄入量 (每天8杯以上) 与女儿早期的青春期有关,但与男孩无关.
科学领域:
- 生殖健康 生殖健康
- 儿科内分泌学 儿科内分泌学
- 人类发展 人类发展
背景情况:
- 产前母亲咖啡消费对人类生殖健康和青春期时间的影响尚不清楚.
- 了解影响青春期开始的因素对于评估长期健康结果至关重要.
研究的目的:
- 调查怀孕早期母亲咖啡消费与女儿和男孩青春期发育时间之间的联系.
- 为了确定母亲高咖啡摄入量是否会影响初潮的年龄,Tanner阶段,语音中断或第一次射精.
主要方法:
- 一项包括15819名儿童在内的队列研究 (青春期队列) 出生于丹麦国家出生队列 (2000-2003) 中的母亲.
- 母亲的咖啡消费在怀孕的第二个三个月初被自我报告;儿童的青春期发育在11岁到18岁之间被自我记录.
- 根据母亲的咖啡摄入量,为女儿和儿子计算了达到青春期里程碑的调整平均差异.
主要成果:
- 每天摄入8杯或更多杯咖啡的母亲的女儿,与不摄入咖啡的母亲的女儿相比,她们的青春期发育大约提前2个月.
- 根据母亲的咖啡消费水平,没有观察到男孩青春期发育时间的显著差异.
- 综合估计显示,暴露于高母咖啡摄入量的女儿早期青春期发育的差异为-2.1个月 (95% CI: -3.9; -0.3).
结论:
- 怀孕期间母亲高咖啡消费量 (≥8杯/天) 可能与女儿早期的青春期发育有关.
- 产前咖啡暴露似乎不会影响男孩青春期发育的时间.
- 需要进一步的研究来证实这些发现,并探索潜在的机制.
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