双相情感障碍患者的euthymic血清中SuPAR水平增加,与执行功能和记忆相关
Burcu Kök Kendirlioğlu1, Esma Çörekli Kaymakçı2, Tuğba Hacıosmanoğlu3
1Ataturk st. Baglarbası dst. No: 3A, 34844, Maltepe University, Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey.
Journal of affective disorders
|January 28, 2026
概括
血清生物标志物基因酶-3样蛋白1 (YKL-40) 和可溶性尿激酶等离子体激活受体 (suPAR) 在双相情感障碍 (BD) 患者中升高. suPAR,而不是YKL-40,与认知缺陷相关,这表明它反映了疾病负担和治疗效应.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 与神经炎症和轴突退化有关,有助于认知障碍.
- 确定BD可靠的生物标志物对于了解疾病机制和进展至关重要.
研究的目的:
- 在BD患者,一级亲属 (FDR) 和健康对照 (HC) 中比较潜在的轴突退化和认知功能障碍生物标志物的血清水平.
- 调查这些生物标志物与BD的认知表现之间的关联.
主要方法:
- 对50名BD患者,42名FDR和53名HC (年龄在18-50岁) 的横截面研究.
- 量化了YKL-40,suPAR,GAP-43和德布林的血清水平.
- 在多个领域进行了全面的神经认知评估.
主要成果:
- 在BD患者中,YKL-40和suPAR水平明显高于FDR和HC患者.
- suPAR,但不是YKL-40,与执行功能,口头记忆和视觉记忆有显著的关联.
- suPAR水平与年龄,疾病持续时间和药物相关,在调整后小组差异减少.
结论:
- 升高的YKL-40和suPAR表明BD中的外周炎症.
- suPAR与认知障碍和临床因素的关联表明,它可能反映了整体疾病负担和治疗效应,而不是针对BD.
- 需要进一步的纵向研究来澄清suPAR在BD中的临床效用.
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