基于功能连接的模块化灵活性预测rTMS治疗抑郁症的疗效
Ying Shao1, Zheyi Zhou2, Junyu Mao3
1Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, China; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of affective disorders
|January 28, 2026
概括
通过提高大脑网络的灵活性,重复性横磁性刺激 (rTMS) 有效地治疗主要抑郁症 (MDD). 治疗前的大脑灵活性预测了治疗反应,为个性化治疗提供了一个生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 重度抑郁症 (MDD) 与大脑电路功能的改变有关,特别是默认模式网络 (DMN).
- 重复性横磁刺激 (rTMS) 是一种有效的MDD治疗方法,但其机制和反应预测因子尚不清楚.
研究的目的:
- 研究rTMS对MDD患者动态功能连接性的影响.
- 确定模块化灵活性变化是否预测使用rTMS治疗的MDD的临床结果.
主要方法:
- 70名接受活跃或虚假rTMS的MDD患者的回顾性分析.
- 休息状态fMRI被用来评估治疗前后的动态功能连接.
- 左背侧前额叶皮层 (lDLPFC) 准rTMS,具有与右核 (NAcc) 作为种子的功能连接.
主要成果:
- 积极的rTMS显著降低了汉密尔顿抑郁评分表 (HAMD) 的得分,而不是假的.
- 治疗增加了中部前额叶皮质 (MPFC) 中的模块化灵活性,这是一个DMN枢纽,与症状减少相关.
- 在DMN节点的基线模块化灵活性预测了治疗后的HAMD得分.
结论:
- rTMS疗法重塑了DMN的动态架构,增强了神经的灵活性.
- 基线模块化灵活性作为个性化rTMS治疗的潜在生物标志物.
- 这项研究推进了神经调节的动态网络模型,强调神经适应性恢复.
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