热应激的综合代谢学和蛋白质学
Shab M Alkhoujah1, Ruba A Zenati2, Munazza Ahmed1
1Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, The University of Sharjah, Sharjah 27272, United Arab Emirates.
Clinica chimica acta; international journal of clinical chemistry
|January 28, 2026
概括
热应激 (HS) 破坏新陈代谢和蛋白质表达,影响细胞功能. 通过代谢学和蛋白质学了解这些分子变化,可以指导热引起损伤的新疗法.
科学领域:
- 环境健康 环境健康
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 热应激 (HS) 是与气候变化相关的日益严重的全球健康问题.
- 对于HS病理生理学的分子机制尚不清楚.
- 目前的HS治疗侧重于缓解症状,没有针对性的预防疗法.
研究的目的:
- 系统地审查对HS的代谢和蛋白质组发现.
- 阐明HS的分子机制.
- 为了确定HS干预的分子标.
主要方法:
- 代谢学研究的系统审查.
- 蛋白质组研究的系统审查.
- 多主题数据的整合.
主要成果:
- 代谢学揭示HS破坏能量代谢,脂质重塑,氧化应激,氨基酸/硫代谢,激素调节和肝脏应激.
- 蛋白质组学显示了像HSP70和HSP90这样的热冲击蛋白 (HSP) 的调节,以及炎症介质,细胞骨蛋白和信号通路的重塑.
- 综合的奥米克数据表明,在HS易感性和适应性方面,有协调的代谢和蛋白质组重编程.
结论:
- 代谢学和蛋白质学为了解HS分子机制提供了强大的工具.
- 综合的多学科方法为HS分子复杂性提供了全面的视图.
- 来自omics数据的见解可以指导HS生物标志物和向治疗的开发.
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