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相关概念视频

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
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Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

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Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
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Acute Coronary Syndrome V: Nursing Management01:26

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Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome
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灾难性的抗脂综合征

Jean-Christophe Gris1,2,3, Mathias Chea1,2, Antonia Perez-Martin2,4

  • 1Department of Haematology, CHU Nîmes, Univ Montpellier, Nîmes, France.

Seminars in thrombosis and hemostasis
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概括

灾难性抗脂综合征 (CAPS) 是一种罕见的,危及生命的疾病,由抗脂抗体引起. 目前的治疗包括抗凝,免疫抑制和抗体中和,但需要新的疗法.

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科学领域:

  • 类风湿病学 类风湿病学
  • 血液学 血液学 血液学
  • 免疫学 免疫学 免疫学

背景情况:

  • 灾难性抗脂综合征 (CAPS) 是一种罕见的,严重的全身自身免疫性疾病.
  • 它的特点是广泛的血栓式微血管病变和细胞因子风暴,通常是由沉因素引发的.
  • 诊断可能具有挑战性,特别是在没有抗脂抗体 (aPL Abs) 病史的患者中.

研究的目的:

  • 总结目前对CAPS临床表现和管理的理解.
  • 突出现有治疗策略的局限性和进一步研究的需要.

主要方法:

  • 审查CAPS注册表中的数据.
  • 对临床表现和治疗管理的现有文献进行分析.
  • 没有随机对照试验可用于指导治疗.

主要成果:

  • CAPS涉及aPL Abs介导的血栓性微血管病变和细胞因子风暴,可能导致出血.
  • 治疗依赖于早期的三重疗法:抗凝,免疫抑制和aPL Abs去除/中和.
  • 预后有所改善,但仍然很差.

结论:

  • 有效管理CAPS需要迅速的三重疗法.
  • 对针对aPL Abs激活的病理生理治疗的进一步研究对于改善患者的治疗结果至关重要.