脑电脑接口治疗在慢性中风中上肢康复的有效性:随机对照试验的系统审查和元分析
HongJie Chen1,2, GuoJun Yun1
1Department of Rehabilitation Medicine, Shenzhen Children's Hospital, Shenzhen City, Guangdong Province, China.
Journal of medical Internet research
|January 28, 2026
概括
脑电脑接口 (BCI) 疗法在慢性中风幸存者中改善上肢功能和日常活动方面表现有前途. BCI功能电刺激 (FES) 方法似乎是最有效的,尽管长期益处需要进一步研究.
科学领域:
- 神经科学与康复工程 神经科学与康复工程
- 临床神经生理学 临床神经生理学
- 生物医学信号处理
背景情况:
- 超过50%的慢性中风幸存者经历了持续的上肢功能障碍.
- 大脑计算机接口 (BCI) 疗法为康复提供了一种新的感觉运动反循环.
- 慢性中风的最佳BCI应用参数仍然不清楚.
研究的目的:
- 评估BCI治疗对慢性中风运动功能,肌肉度和日常生活活动 (ADL) 的疗效.
- 确定最佳的BCI反方式和干预参数.
- 通过元分析综合随机对照试验 (RCT) 的证据.
主要方法:
- 在主要数据库 (PubMed,Embase,Scopus等) 的系统文献搜索. 在2025年10月之前.
- 使用随机效应模型对21个RCT (650名参与者) 的元分析.
- 主要结局包括上肢运动功能 (FMA-UE,ARAT),肌肉度 (MAS) 和ADL (MBI,MAL).
主要成果:
- BCI训练显著改善了上肢运动功能 (FMA-UE) 和ADL性能 (MBI,MAL).
- 对于精细运动技能 (ARAT) 或肌肉强度 (MAS) 没有发现显著影响.
- BCI功能电刺激 (FES) 显示出最大的运动恢复改善;最佳方案涉及30分钟的会议,每周4-5次,持续2周,但效益没有持续.
结论:
- 低至中度确定性证据表明,BCI,特别是BCI-FES,可以改善慢性中风中的运动功能和ADL.
- 广泛的预测间隔表明效应的变化很大; 建议的最佳方案是初步的.
- 需要进一步的高质量的RCT来验证协议,确定患者子组,并制定可持续收益的策略.
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