相关实验视频
Updated: Jan 30, 2026

08:26
Measuring the 50% Haemolytic Complement CH50 Activity of Serum
Published on: March 29, 2010
38.9K
从狗咬到透析:补充介导的溶血性尿素性综合征
Tobias Evason Fredriksen1, Burhan-Ud-Din Mian2, Szilveszter Dolgos2
1Department of Nephrology, Sykehuset Østfold HF, Grålum, Norway tobfredrik@gmail.com.
BMJ case reports
|January 28, 2026
概括
在成年人中,狗咬伤导致败血症和血栓性微血管病变 (TMA). 迅速治疗eculizumab和血交换有助于实现缓解和部分恢复.
科学领域:
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
背景情况:
- *Capnocytophaga canimorsus是一种常见于狗和猫中的细菌.
- *败血症可能导致严重的并发症,包括扩散性血管内凝血和急性损伤.
- * 血栓式微血管病 (TMA) 是一组疾病,其特点是微血管病性血液溶解性贫血,血栓细胞减小和器官损伤.
研究的目的:
- * 报告一种罕见的Capnocytophaga canimorsus感染病例,在一个免疫能力强的成年人中引发补充介导血清性尿素综合征 (CM-HUS).
- *为了描述TMA在败血症后的诊断挑战和治疗方法.
- *强调在TMA的差异诊断中考虑罕见传染病原体的重要性.
主要方法:
- * 一个以前健康的40多岁妇女的病例报告.
- *分析了临床表现,实验室发现和脏活检结果.
- *治疗包括抗生素,支持性护理,血交换和eculizumab治疗.
主要成果:
- * 患者在狗咬后出现了败血症,扩散性血管内凝血,全细胞减小和急性损伤.
- * 血液培养物证实了Capnocytophaga canimorsus bacteremia的发生.
- * 通过实验室和活检结果证实了补充介导的血溶性尿素综合征 (CM-HUS) 的诊断.
- * 用血交换和eculizumab治疗导致了血液学缓解和部分功能恢复.
结论:
- *Capnocytophaga canimorsus感染可能是免疫能力强的成年人中CM-HUS的罕见触发因素.
- * 早期诊断和适当的治疗,包括血交换和eculizumab,对于治疗败血症后的TMA至关重要.
- * 这一案例强调了在严重感染的情况下诊断和管理TMA的复杂性.
相关概念视频
Dialysis
1.4K
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
1.4K
Dialysis
1.8K
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
1.8K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
725
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
725
Complement System
10.5K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
10.5K
Complementation Tests
6.2K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.2K
Peritoneal Dialysis I: Introduction and Procedure
3.0K
Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
3.0K

