全球后神经疼痛的流行病学和危险因素:系统审查和元分析的协议
Xuran Liao1,2, Shihao Xu3, Yufeng Wang4
1Department of Pain Management, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
BMJ open
|January 28, 2026
概括
这一系统性审查将更新 postherpetic neuralgia (PHN) 流行病学的全球估计,并确定关键风险因素. 了解这些因素对于制定PHN有效的预防和治疗策略至关重要.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 疼痛医学 医学 疼痛医学
背景情况:
- 后神经疼痛 (PHN) 是疹 (HZ) 的严重并发症,严重影响患者的生活质量,并构成全球健康挑战.
- 关于PHN风险因素和全球流行病学趋势的现有研究是分散的,需要更新,全面的分析.
- 确定可修改和不可修改的风险因素对于有针对性的预防和改善PHN治疗干预措施至关重要.
研究的目的:
- 进行系统性审查和元分析,以确定PHN流行和发病率的最新全球估计.
- 综合关键风险因素与PHN流行和严重程度相关.
- 为公共卫生战略和PHN的临床管理提供信息.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA指南.
- 在多个数据库 (MEDLINE,Embase,Web of Science等) 中进行全面的文献搜索. 对于英语/中文研究,截至2025年4月.
- 包括报告PHN流行/发病率或风险因素的成人研究;使用JBI工具和ROBINS-I进行数据提取和偏差风险评估;随机效应对流行率和风险因素的元分析,包括子组和敏感性分析.
主要成果:
- 本节将介绍全球PHN流行和发病率的综合估计.
- 它将确定和量化各种风险因素 (例如,年龄,疫苗接种状况,急性疼痛严重程度,并发症) 与PHN的关联.
- 结果将按地理区域,收入水平和临床/人口因素进行分层,以突出流行病学异质性.
结论:
- 这一系统性审查将为PHN流行病学提供当代的全球概述.
- 将阐明PHN患病率和严重程度的关键决定因素,为有针对性的干预提供见解.
- 研究结果将指导基于证据的预防策略的制定,并优化PHN影响的个体的治疗方法.
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