支气管肺功能障碍患病率的变化和定义上的结果:来自中国新生儿网络的多中心队列研究
Ge Yang1, Ling Wang1, Cuizhen Gao1
1Division of Neonatology and Center for Newborn Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
BMJ open
|January 28, 2026
概括
支气管肺功能障碍症 (BPD) 在中国非常早产婴儿中很常见. 申南1988年,NICHD2018年和NRN2019年定义显示出与NICHD2001年相比,排放结果的良好一致性和更好的预测准确性.
科学领域:
- 新生儿科学 新生儿科学
- 儿科肺病学 儿科肺病学
- 流行病学 流行病学
背景情况:
- 支气管肺功能障碍症 (BPD) 是非常早产婴儿的一种严重并发症.
- 准确的BPD诊断和预测结果对于临床管理至关重要.
研究的目的:
- 分析中国非常早产婴儿的BPD流行病学数据.
- 为了比较四个BPD诊断定义对出院结果的一致性和预测准确性.
主要方法:
- 一项观察性多中心队列研究,涉及42,664名早产婴儿 (<32周妊娠年龄) 从2019-2023.
- 使用Shennan 1988,NICHD 2001,NICHD 2018和NRN 2019的定义进行BPD诊断.
- 通过kappa统计评估协议;使用c-统计评估预测准确性.
主要成果:
- 根据定义,BPD的患病率有所不同 (Shennan 1988: 37.0%,NICHD 2001: 51.1%,NICHD 2018: 37.0%,NRN 2019: 37.0%). 根据定义,BPD的患病率有所不同 (Shennan 1988: 37.0%,NICHD 2001: 51.1%,NICHD 2018: 37.0%,NRN 2019: 37.0%).
- 与NICHD 2001 (0.854-0.925) 相比,Shennan 1988年,NICHD 2018年和NRN 2019年定义显示出出院结果的歧视性准确性更高 (c统计范围:0.921-0.982).
- 在Shennan 1988和NICHD 2018 (κ=1.0) 和Shennan 1988和Jensen 2019 (κ=1.0) 之间观察到良好的协议.
结论:
- 在中国非常早产婴儿中,BPD的高患病率,根据诊断标准有显著的差异.
- 由于它们的一致性和预测准确性,Shennan 1988,NICHD 2018和NRN 2019的定义被推用于临床使用.
- 这些发现支持优先考虑特定的BPD定义,以改善这一群体的临床决策.
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