癌症免疫疗法天然产品的最新进展
Taiqing Liu1, Jinhua Zhao1, Ziying Yao1
1Department of Pharmacy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Phytotherapy research : PTR
|January 28, 2026
概括
自然产品 (NP) 可以通过调节瘤免疫微环境来增强癌症免疫疗法. 这篇评论详细介绍了NP如多糖和黄类药物如何激活免疫细胞并与其他疗法协同作用.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 自然产品 (NPs) 在抗癌药物发现中至关重要,但在癌症免疫治疗中未得到充分利用.
- 了解它们的免疫调节机制是将NP纳入癌症治疗的关键.
研究的目的:
- 在癌症免疫治疗中提供基于NP的机制和分类的审查.
- 通过其在瘤免疫微环境中的免疫调节功能来组织NP.
- 以指导基于NP的组合免疫疗法的合理设计.
主要方法:
- 基于免疫调节机制的代表性NP (多糖,黄,类,类) 的分类.
- 阐明NP对免疫细胞透,效应因子反应和细胞因子信号传递的影响.
- 综述了涉及NP与免疫检查点抑制剂和抗体-药物联合体的组合策略.
主要成果:
- 通过增强免疫细胞透和激活效应反应,NP重塑瘤免疫微环境.
- 核细胞再编程细胞因子信号传递网络对于抗瘤免疫至关重要.
- 作为单一药物和组合疗法,NP显示出克服耐药性的潜力.
结论:
- 建立了一个连贯的框架,将NP药理与免疫瘤学联系起来.
- 国家医疗机构为组合免疫疗法提供了有希望的策略,以加强临床转化.
- 对基于NP的组合疗法的进一步研究可以加速临床应用.
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