角膜共聚焦显微镜作为神经退行性疾病的临床试验:一个范围审查
Emma Oreskovic1,2, Axel Petzold3,4, Ioannis Nikolaos Petropoulos5
1University Eye Hospital Svjetlost, Zagreb, Croatia rmhkego@ucl.ac.uk.
The British journal of ophthalmology
|January 28, 2026
概括
角膜共聚焦显微镜 (CCM) 在神经退行性疾病中显示角膜神经纤维密度和长度减少. 这种技术显示出作为外围神经退行症的生物标志物具有前途,特别是在帕金森病和多发性硬化症中.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 生物标志物研究 生物标志物研究
背景情况:
- 角膜共聚焦显微镜 (CCM) 不侵入地量化角膜下基底神经.
- CCM是外围神经退行症的一个潜在的替代生物标志物.
- 评估角膜神经纤维的变化有助于理解神经退行性疾病 (NDD).
研究的目的:
- 审查关于角膜神经纤维NDD变化的CCM证据.
- 探索CCM作为NDD的诊断和监测工具的潜力.
- 为了确定神经退行症可靠的CCM指标.
主要方法:
- 根据PRISMA-ScR指南进行范围审查.
- 在PubMed和Scopus中搜索了定量CCM指标 (CNFD,CNBD,CNFL).
- 包括50项跨越各种NDD的研究 (帕金森氏症,多发性硬化症,COVID-19神经病变等). ) 的情况.
主要成果:
- 在大多数研究的NDD中,角膜神经纤维长度 (CNFL) 和密度 (CNFD) 始终降低.
- 视角神经分支密度 (CNBD) 的结果在研究中不一致.
- 最强有力的证据支持CCM在帕金森病和多发性硬化症中.
结论:
- CNFL和CNFD是神经退行症的可靠CCM指标.
- CCM显示出作为NDDs的临床诊断工具的潜力.
- 对于CCM更广泛的临床应用,需要标准化的协议.
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