一个独特的电路,用于偏向视觉感知决策,并通过小鼠的后条纹体调节上级结核活动.
Kara K Cover1, Kerry Elliott2, Sarah M Preuss2
1Laboratory of Sensorimotor Research, National Eye Institute Bethesda, Maryland 20892 USA richard.krauzlis@nih.gov kara.cover@nih.gov.
概括
后条纹体 (PS) 通过与背中条纹体 (DMS) 截然不同的途径控制动物的视觉决策. 激活PS路径会偏向基于背景和奖励的决策,调节上层结体 (SC).
科学领域:
- 神经科学是一个神经科学.
- 决策方式 决策方式
- 视觉处理 视觉处理
背景情况:
- 基底腺节对于视觉感知决策至关重要.
- 后条纹体 (PS) 接收显著的视觉输入,但其作用尚未被探索.
- 背中条体 (DMS) 是已知的视觉皮层输入的途径.
研究的目的:
- 调查PS在视觉感知决策中的作用.
- 为了比较PS直接路径与DMS直接路径.
- 通过这些途径检查上结肠 (SC) 的调制.
主要方法:
- 在小鼠的PS和DMS中D1-MSN的光遗传刺激.
- 小鼠执行了一个视觉变化检测任务.
- 在SC中记录了神经元活动.
主要成果:
- PS D1-MSN激活基于上下文,时间和奖励的视觉决策.
- PS和DMS直接通路在解剖学上是分离的.
- 这两种途径都调节了SC神经元活动,针对不同的神经元,具有相反的效果.
结论:
- PS提供了一个独特的路线来控制视觉决策,并行于DMS.
- 该PS通路具有独特的解剖学和功能性质.
- 这些发现揭示了一种用于视觉决策的新的基底质回路.
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