在复发性或耐火性多发性骨髓瘤治疗期间,外骨髓性病变的伪进展
Akihiro Kawatsuki1, Hiroki Kobayashi1,2, Shoka Kimura3
1Department of Hematology and Oncology, Japanese Red Cross Society Himeji Hospital, Himeji-shi, Hyogo, Japan.
Journal of clinical and experimental hematopathology : JCEH
|January 28, 2026
概括
伪进展是elranatamab免疫疗法的罕见副作用,涉及由于免疫反应导致的暂时瘤生长. 将其与真正的进展区分开来,对于有效的多发性骨髓瘤治疗至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 临床案例研究 临床案例研究
背景情况:
- 伪进展是免疫治疗后瘤负担的短暂增加.
- 它是由免疫细胞透或炎症引起的.
- 埃拉拉纳塔马布的伪进展病例很少见.
研究的目的:
- 描述一种罕见的伪进展病例,该病例发生在用elranatamab.b.治疗的患者身上.
- 强调区分伪进展与真正进展的重要性.
主要方法:
- 一个67岁的女性病例报告,患有复发性/耐火性多发性骨髓瘤.
- 使用了临床评估,CT成像和CT导向活检.
- 治疗包括埃拉拉纳他马布和甲.
主要成果:
- 患者出现了扩大的外骨头病变和眼部症状,最初表明病情进展.
- 组织病理学证实了密集的T细胞透,表明了伪进展.
- 患者对elranatamab的反应是M蛋白减少和病变减少.
结论:
- 假进展可能发生在elranatamab,一个T细胞重定向免疫疗法.
- 准确的诊断至关重要,以避免过早停止治疗.
- 临床和成像评估,包括组织病理学,艾滋病管理.
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