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一种转换生物等价DVH的方法,用于放射治疗中的不同分量,并具有内置脚本

Siyao Zhong¹, Jiahao Su², Han Guo³

¹Department of Radiotherapy, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists

|January 28, 2026

概括

与标准EQD2方法相比,新的EQDd方法为中度低分离放射治疗 (mHFRT) 计划提供了比标准EQD2方法更准确的生物转换剂量. 这种改进的方法提高了癌症治疗中风险器官 (OAR) 剂量的评估.

科学领域:

放射治疗物理物理
辐射瘤学辐射瘤学
医学物理医学物理

背景情况:

现代放射疗法利用多种不同的分成方案,对中度低分成放射疗法 (mHFRT) 计划的剂量评估提出了挑战.
标准剂量相当于2Gy/分数 (EQD2) 转换方法对mHFRT剂量-体积组图 (DVH) 分析有局限性,原因是固定的分数假设.

研究的目的:

开发和验证一种改进的方法,用于将mHFRT物理DVH转换为用于常规分离放射治疗 (CFRT) 的同等DVH.
解决临床实践中mHFRT现有的DVH转换技术的局限性.

主要方法:

引入了EQDd (相当剂量以d Gy分数) 方法,该方法在mHFRT DVH转换中解释了可变的每分数剂量,而不是EQD2中的常数2 Gy分数.
通过将EQDd方法与胸部DVHs的EQD2方法进行比较,根据不同的分成处方 (2 Gy x 30, 3 Gy x 20, 4 Gy x 15) 验证了EQDd方法.
使用Eclipse脚本应用程序编程接口 (ESAPI) 为Eclipse治疗计划系统开发了一个自动化的DVH转换插件.

主要成果:

EQDd转换准确地反映了传统分化 (2 Gy x 30) 的DVH,而EQD2低估了风险器官 (OAR) 剂量.
对于mHFRT计划 (3 Gy x 20, 4 Gy x 15),EQDd转换显示了更高的等效剂量,表明与EQD2相比,生物效应更大.
对于全面的DVH模式评估,EQD2是有限的,而EQDd则为mHFRT提供了更生物学相关的剂量-体积关系.
开发的"DVH转换"插件可以快速自动化EQDd转换.

结论:

在mHFRT中评估OAR剂量时,EQD2方法存在显著的局限性,特别是在体积剂量评估方面.
EQDd方法为mHFRT提供了更生物学准确的DVH转换,提高了临床剂量评估和治疗规划.
开发的基于ESAPI的插件有助于高效,准确的临床实施EQDd转换.

关键词:

传统的分离辐射疗法.剂量测量评估的评估方法这是ESAPI的ESAPI.相当剂量相当于剂量.低分数放射疗法低分数放射疗法

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