睡眠时间和质量与小密度低密度脂蛋白胆固醇的关联
Tomoaki Yamada1, Yasushi Yamamoto2, Ryoko Toragai3
1Department of Insured Medical Care Management, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan (Yamada, Dr Nakamura, and Dr Ai).
Journal of clinical lipidology
|January 28, 2026
概括
睡眠质量差与较高的小密度低密度脂蛋白胆固醇 (sdLDL-C) 水平有关,这是心血管疾病的危险因素. 改善睡眠质量可能有助于管理脂质配置文件并预防心脏病.
科学领域:
- 心血管健康 心血管健康
- 睡眠医学 睡眠医学
- 脂质代谢 脂质代谢是什么
背景情况:
- 关于睡眠质量与脂质状况之间的关联的证据有限.
- 心血管疾病 (CVD) 风险受脂质参数的影响.
- 睡眠时间与心血管疾病和脂质的联系得到了充分研究,但睡眠质量的作用需要进一步研究.
研究的目的:
- 为了检查日本人口的睡眠时间,睡眠质量和脂质参数之间的关系.
- 具体研究与血清中小密度低密度脂蛋白胆固醇 (sdLDL-C) 水平的相关性.
主要方法:
- 一项对24,984名接受医疗检查的日本成年人的横截面研究.
- 睡眠时间 (分类为<6,6-8或≥8小时) 和睡眠质量 (好与差) 通过自我报告问卷进行评估.
- 测量了血清脂质配置文件,包括sdLDL-C;进行了多变量分析.
主要成果:
- 睡眠质量差与睡眠时间<6小时和6-8小时的个体中高的中位数SDLDL-C水平显著相关,无论男女.
- 在睡眠时间≥8小时的组中,在良好的睡眠者和不良睡眠者之间没有观察到sdLDL-C的显著差异.
- 多变量回归证实,睡眠质量差独立预测高的sdLDL-C水平.
结论:
- 睡眠质量差是与不利的脂质样本相关的重要因素,特别是高的sdLDL-C.
- 睡眠质量是一种可修改的生活方式因素,可能在减少脂质异常方面发挥作用.
- 解决睡眠质量问题可能是预防心血管疾病的策略.
相关概念视频
Cholesterol: Significance and Regulation
1.4K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.4K
Insufficient Sleep and Sleep Deprivation
932
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
932
Dense Connective Tissue
12.0K
Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
12.0K
Stages of Sleep
1.4K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.4K
Understanding Sleep
1.5K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.5K
Sleep Apnea
549
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
549


