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年轻患者心肌梗塞的趋势
Mahmoud Khalil1, Dharmindra Dulal2, Ahmed Younes3
1Cardiology department, university of Connecticut, Farmington, CT, United States of America.
概括
ST升高心肌梗塞 (STEMI) 的发病率,死亡率和机械循环支持 (MCS) 的使用在18-40岁的年轻人中显著增加. 这一令人担忧的趋势,尤其是在COVID后,迫切需要对预防和治疗策略进行研究.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 虽然ST升高心肌梗塞 (STEMI) 的总体发病率有所下降,但在年轻成年人 (18-40岁) 中观察到增加发病率和死亡率的令人担忧的趋势.
- 了解STEMI在这个人口群体中的发展轨迹对于开发有针对性的公共卫生干预措施至关重要.
研究的目的:
- 研究18-40岁的年轻成年人中STEMI发病率,死亡率和机械循环支持 (MCS) 的使用趋势.
- 评估研究期间同一队列内主要心血管风险因素的变化.
主要方法:
- 来自TriNetX研究网络数据库 (2004-2023) 的18-40岁的大队列 (34,888,311名患者) 的分析.
- 使用线性回归来评估STEMI的发病率,死亡率和MCS利用率.
- 评估心血管风险因素,包括糖尿病,高血压,尼古丁依赖,肥胖和物质使用障碍.
主要成果:
- 从2004年到2023年,STEMI发生率显著增加 (1.59/100,000人年).
- 死亡率每年增加108/100,000,MCS利用率增加了38.8/100,000.
- 在这个年轻成年人群中,主要心血管风险因素的显著增加也被观察到.
结论:
- 在2004年至2023年期间,STEMI发病率,死亡率和MCS利用率在年轻成年人中显著增加.
- 在后COVID时代观察到更的上升趋势,突显了进一步调查的迫切需要.
- 在年轻人中,有效的STEMI预防和治疗策略,特别是在COVID后的背景下,需要立即关注研究.
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