脉冲性神经内分泌瘤:多中心经验和内镜治疗的新兴前景
Federica Fimiano1, Lorenzo Dioscoridi2, Marta Stegagnini2
1Digestive Endoscopy Unit, AOU San Giovanni e Ruggi-Fucito Unit, Salerno, Italy.
Rambam Maimonides medical journal
|January 28, 2026
概括
透视乳头切除术 (EP) 是对精选的囊神经内分泌瘤 (NETs) 的可行的替代方案,提供高完全切除率和有利的短期结果. 谨慎的监测对于管理残留或反复的NET至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 手术内镜是指手术内镜.
背景情况:
- 腹膜神经内分泌瘤 (NETs) 很少见,占周围腹膜癌症的<2%.
- 目前的指导方针建议针对囊性NET进行侵袭性胰腺双管切除术 (PD).
- 内镜乳头切除术 (EP) 正成为一种不那么侵入性的替代方案.
研究的目的:
- 评估囊性NET的内镜切除的可行性和结果.
- 评估EP后的完全切除率,复发率和不良事件.
- 将EP结果与传统的外科手术方法进行比较.
主要方法:
- 14名患者的回顾性病例系列,他们接受了AMPULLAR NET的EP (2011-2022年).
- 在监控镇静下进行的标准内镜乳头切除术.
- 3个月后进行后续内镜检查;主要结局:完全切除 (R0) 和复发.
主要成果:
- 在78.6% (11/14) 的病例中实现了完全切除 (R0).
- 随访14.5个月的中位数显示没有复发.
- 不良事件 (42.9%) 包括出血和轻微的胰腺炎,所有这些都没有后果.
结论:
- 对于精选的脉冲性NET,EP是手术的有希望的替代方案.
- 内镜切除显示了高的R0率和有利的短期结果.
- 需要进一步的前性研究来优化患者选择和长期疗效.
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