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Updated: Jan 30, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
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Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Published on: October 23, 2019

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阐明蛋白质-蛋白质相互作用在调节抑制剂亲和和释放机制中的作用 氨酸蛋白质激酶

Shreya Mukherjee1, Niladri Patra1

  • 1Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM) Dhanbad, Dhanbad 826004, India.

The journal of physical chemistry. B
|January 28, 2026
PubMed
概括

这项研究揭示了MSC1186等小分子如何与ASF-SRPK蛋白质复合体相互作用,通过了解这些关键的蛋白质-蛋白质相互作用,为癌症治疗提供了新的见解.

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Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
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Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
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Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein Networks

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A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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