益生菌酸是一种来自肠道的饮食代谢物,通过GPER介导的NO信号减轻内皮功能障碍
Seung Yeon Lee1, Jae Won Kim1, Anh Thi Ngoc Bui1
1College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
Journal of agricultural and food chemistry
|January 28, 2026
概括
甲基酸 (PCA) 通过增强氧化的产生和减少炎症来保护血管. 这种多代谢物显示出预防心血管疾病的潜力.
科学领域:
- 心血管科学 心血管科学
- 分子生物学分子生物学
- 营养科学 营养科学
背景情况:
- 饮食中的多醇会产生诸如甲酸 (PCA) 等代谢物.
- PCA显示出内皮细胞的保护作用,但机制尚不清楚.
- 内皮功能障碍有助于心血管疾病.
研究的目的:
- 阐明PCA在减轻内皮功能障碍中的分子途径.
- 研究PCA对内皮氧化合成酶 (eNOS) 信号传输的影响.
- 为了探索PCA的抗炎和血管松性质.
主要方法:
- 利用人类内皮细胞研究PCA的影响.
- 研究了G蛋白结合雌激素受体 (GPER) 和下游信号通路 (CaMKKβ/AMPK,CaMKIIα).
- 分析了KLF2/eNOS轴,转录网络 (HDAC5,ERK5/MEF2C) 和NF-κB激活.
主要成果:
- 通过GPER介导的信号传递,PCA增加了eNOS表达和酸化.
- 观察到CaMKKβ/AMPK和CaMKIIα通路的激活.
- 通过PCA上调KLF2/eNOS轴,并抑制TNF-α诱导的NF-κB激活.
- 观察到依赖氧化抑制粘附分子 (ICAM-1,VCAM-1) 和减少单细胞粘附.
- 通过增强eNOS活动,PCA改善了大动脉血管松.
结论:
- 通过通过GPER进行eNOS信号传输,PCA对内皮进行保护.
- PCA可以减轻炎症并改善血管功能.
- 作为预防心血管疾病的功能性食品成分,PCA具有潜力.
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