事件缺口的率和决定因素:系统审查和元分析
Fei Han1, Dingding Zhang2, Joanna Wardlaw3,4
1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
概括
新的缺口,脑小血管疾病的关键标志物,在不同的人群中以不同的速度发生. 发病率受到基线缺口负担和血管风险因素 (如高血压和糖尿病) 的影响.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 流行病学 流行病学
背景情况:
- 缺口,据推测是血管起源的,是脑小血管疾病 (cSVD) 的关键成像标志物.
- 这些缺陷预测了中风和痴呆风险,但它们的发病率和决定因素在不同人群中没有得到充分量化.
- 了解缺口发生率对于临床研究和样本大小估计至关重要.
研究的目的:
- 估计各种人群中新缺口的年均发病率.
- 确定影响跨研究间缺口发病率异质性的因素.
- 总结患者层面的新缺口发展的风险因素.
- 为了在使用事件缺口作为结果的研究中提供样本大小计算的数据.
主要方法:
- 一个系统的审查和对31项研究的元分析.
- 包括12,646名参与者和56,073人年后续数据.
- 超回归分析以确定研究水平和患者水平的因素.
主要成果:
- 新缺口的综合发病率为每100人/年3.27.
- 发病率差异很大,在脑小血管疾病患者中最高 (8.03/100人年).
- 个人风险因素包括男性性别,基线缺口,高血压和糖尿病.
- 为检测cSVD群体30%的相对风险降低,为不同后续持续时间提供了样本大小计算.
结论:
- 事件缺口率在不同的人口之间存在很大差异.
- 基线缺口负担和血管风险因素显著影响缺口发生率.
- 调查结果为对事件缺口的研究提供了人口选择和样本大小考虑的信息.
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