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Updated: Jan 30, 2026

Homing of Hematopoietic Cells to the Bone Marrow
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修改CXCR4通过改善B细胞恶性瘤中的瘤跟踪和骨髓定位来提高CAR-T疗效

Pei Shu1,2, Fuchun Guo2,3, Diyuan Qin2,3

  • 1Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Signal transduction and targeted therapy
|January 28, 2026
PubMed
概括

设计CAR-T细胞过度表达CXCR4可以提高它们向B细胞恶性瘤的能力. 这一策略改善了瘤追踪,骨髓定位,并延长了抗瘤活性,在血液癌症的临床试验中显示出有前途.

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