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Updated: Jan 30, 2026

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在泰国成年人中建模饮食-肠道微生物群相互作用和益生菌反应
Nachon Raethong1, Preecha Patumcharoenpol2,3, Wanwipa Vongsangnak4
1Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand. nachon.rae@mahidol.ac.th.
NPJ biofilms and microbiomes
|January 28, 2026
概括
这项研究将泰国饮食数据与肠道微生物组模型相结合,揭示了食物如何影响微生物代谢. 结果显示个性化的短链脂肪酸 (SCFA) 生产,并识别了针对目标营养对益生菌有反应的关键微生物.
科学领域:
- 微生物组研究的研究.
- 系统生物学 系统生物学
- 营养科学 营养科学
背景情况:
- 饮食显著影响肠道微生物代谢,对健康干预至关重要.
- 了解这些相互作用是制定有效的基于微生物组的策略的关键.
- 个性化营养需要详细了解饮食微生物组动态.
研究的目的:
- 开发一个系统生物学管道,将泰国饮食数据与肠道微生物组模型集成在一起.
- 模拟肠道微生物代谢并评估泰国人口对益生菌补充剂的反应.
- 确定短链脂肪酸 (SCFA) 生产和益生菌反应的微生物驱动因素.
主要方法:
- 利用泰国健康成年人的基因组数据和全国饮食调查.
- 从基因组规模代谢模型 (GSMMs) 开发了社区规模代谢模型 (CSMMs).
- 应用流量变化分析来评估与微生物分类学相对的代谢能力和SCFA生产.
主要成果:
- 在SCFA概况中发现了显著的个体间变异性.
- 鉴定出巴克特罗伊德和福凯科拉作为同位素酸盐的关键生产者.
- 证明了Bifidobacterium作为一种对益生菌补充剂的主要反应者.
结论:
- 综合性框架提供了对饮食与肠道微生物群相互作用的生物学见解.
- 这种方法支持为泰国人口开发精准营养策略.
- 强调了基于个体微生物组代谢的定制饮食干预措施的潜力.
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