智能药盒干预措施的成本效益,以遵守口服HIV暴露前预防
Zhen-Hao Wu1,2,3,4, Zhen-Xing Chu1,2,3,4, Yi-Ling Meng1,2,3,4
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, NHC Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University, Shenyang, China.
Nature communications
|January 28, 2026
概括
一个数字智能药盒干预措施改善了中国与男性发生性关系 (MSM) 的男性口服预暴露预防 (PrEP) 的坚持. 这种工具是一种具有成本效益的战略,特别适用于低收入和中等收入国家 (LMICs) 的社会弱势群体.
科学领域:
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
- 数字健康干预措施 数字健康干预措施
背景情况:
- 口服暴露前预防 (PrEP) 是有效的,但与男性发生性关系的男性 (MSM) 仍然存在坚持挑战.
- 数字合规工具需要经济验证才能在低收入和中等收入国家 (LMIC) 实施.
研究的目的:
- 评估DIRECT-PrEP数字干预措施在6个月的成本效益,以提高中国口服PrEP的遵守率.
- 从卫生系统,多层次和社会角度评估干预措施.
主要方法:
- 一项随机对照试验,涉及442名参与者 (247名干预,195名标准护理).
- 来自医院记录的成本;以质量调整的寿命年 (QALYs) 和PrEP遵守日 (PADs) 来衡量有效性.
主要成果:
- 每个获得的QALY的增量成本低于成本效益值 (19,575.93美元至19,844.42美元).
- 每个获得的PAD成本在30.46美元至30.86美元之间,成本效益概率>95%.
- 这种干预对社会脆弱的参与者来说更具成本效益.
结论:
- DIRECT-PrEP智能药盒干预是改善LMICs口服PrEP遵守的成本效益高的策略.
- 优先考虑社会弱势群体可以提高干预的成本效益.
- 为了实现长期可扩展性,需要进一步验证.
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