按更年期状态遵守口服内分泌疗法:从远程监测随机试验中获得的后期见解
Ilana Graetz1,2, Xin Hu3,4, Rebecca A Krukowski5
1Rollins School of Public Health, Emory University, Atlanta, GA, USA. ilana.graetz@emory.edu.
NPJ breast cancer
|January 28, 2026
概括
基于应用程序的远程监测显著提高了绝经前乳腺癌患者的口服辅助内分泌治疗的坚持. 这个数字健康工具对改善年轻女性的治疗坚持有希望.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 数字健康数字健康
背景情况:
- 辅助内分泌疗法 (AET) 对激素受体阳性乳腺癌的生存至关重要.
- 年轻的绝经前妇女面临着坚持口服AET的挑战.
- 坚持差距会影响治疗效率和患者的治疗结果.
研究的目的:
- 评估基于应用程序的远程症状监测对绝经前妇女AET遵守的有效性.
- 评估远程监测对绝经后妇女AET遵守的影响.
- 确定潜在的数字健康解决方案,以改善乳腺癌治疗的坚持.
主要方法:
- 一项涉及304名患者的随机试验的后期分析.
- 基于应用程序的远程监控和增强的常规护理 (EUC) 之间的12个月AET遵守情况的比较.
- 对绝经前和绝经后妇女进行分层分析.
主要成果:
- 基于应用程序的远程监测显著改善了绝经前妇女的12个月AET遵守率 (53.9%vs. 25.0%在EUC).
- 在使用远程监测的绝经后妇女中,没有观察到AET坚持的显著益处.
- 该干预表明,年轻患者队列的坚持显著增加.
结论:
- 基于应用程序的远程症状监测是一种可行的策略,可以改善绝经前乳腺癌患者的AET坚持.
- 数字健康干预措施可能有助于弥合接受内分泌治疗的年轻女性的坚持差距.
- 需要进一步的前性研究来证实这些发现,并探索更广泛的应用.
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