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中年和老年人的骨质疏松症和心脏重塑:一个横截面研究

Haoran Wang¹, Qichao Wang², Bing He³

¹Cardiovascular Institute of Luohe, Luohe Central Hospital, Luohe Medical College, Luohe, 462003, China. washingtonhr@163.com.

Scientific reports

|January 28, 2026

概括

较低的骨矿物质密度 (BMD) 与心脏变化有关,例如左心房扩大和心脏壁厚. 骨质疏松症患者的这些发现表明,骨损失和心血管重塑之间有共同的途径.

科学领域:

心血管医学心血管医学
骨的新陈代谢骨的新陈代谢
老年学是一门学科.

背景情况:

骨质疏松症和心血管疾病 (CVD) 普遍存在,特别是在老年人群中.
骨矿物质密度 (BMD) 和心脏结构/功能之间的复杂关系需要进一步阐明.

研究的目的:

在一项队列研究中调查骨质量和心脏参数之间的关联.
确定潜在的共享病理生理机制,将骨损失和心脏重塑联系起来.

主要方法:

对来自骨关节炎和心血管健康队列的1233名参与者的横截面分析.
使用T分数评估的BMD被分为正常,骨质疏松症和骨质疏松症.
通过心声学评估心脏结构和功能,测量诸如左心房体积指数 (LAVI) 和相对壁厚 (RWT) 等参数.
多变量线性回归模型根据年龄,性别和心血管风险因素进行调整.

主要成果:

骨质疏松症与LAVI和RWT的显著增加有关,与正常的BMD相比.
在多变量调整后,较低的BMD (T-score) 与LAVI和RWT独立且反向相关.
这些关联在女性和50岁以下的参与者中更为明显.
没有发现与左心室质量指数,射出分数或透缩功能的显著关联.

结论:

减少的BMD独立地与左心房扩大和心室室壁厚度增加有关.
这些发现表明,共同的潜在机制有助于骨损失和心脏重塑.
需要进一步的研究来探索这些相互关联的病理生理路径.

关键词:

心脏结构的心脏结构横截面研究横截面研究心声回声扫描 (Echocardiography) 是一种心声回声扫描.左心房的体积在左心房.骨质疏松症是一种骨质疏松症.相对的墙壁厚度相对的墙壁厚度

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