米托克桑在恶性脑瘤模型中改变了CD24/Siglec-10表达
Jan Kopecky1, Julio Enríquez Pérez1, Stevanus Jonathan1
1Department of Clinical Sciences Lund, Neurosurgery, Lund University, Lund, Sweden.
Scientific reports
|January 28, 2026
概括
米托克桑治疗降低了恶性脑瘤细胞的CD24水平,并减少了免疫抑制的Siglec-10+细胞. 这种对CD24/Siglec-10轴的向可能会增强抗瘤免疫力.
科学领域:
- 神经瘤学神经瘤学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 脑髓母细胞瘤和脑髓母细胞瘤是常见的原发性脑瘤.
- 与瘤相关的巨细胞/微细胞通过Siglec-10与瘤细胞上的CD24相互作用,促进免疫逃避.
- 大脑瘤中的CD24/Siglec-10轴尚未得到研究.
研究的目的:
- 研究CD24/Siglec-10轴在恶性脑瘤中的作用.
- 评估米托克桑对这一轴的影响和抗瘤免疫力.
主要方法:
- 在CD24基因表达的分析.
- 在人类和小鼠脑瘤中对Siglec-10和TREM2联合表达的分析.
- 在实验室中对用米托克桑治疗的大脑瘤细胞培养物的研究.
- 在活体研究中,使用了用瘤治疗的小鼠质瘤模型.
主要成果:
- CD24表达与脑髓母细胞瘤和脑髓母细胞瘤的预后相关.
- 在脑瘤中,Siglec-10+细胞共同表达TREM2.
- 在体外,米托克桑降低了细胞活力和CD24水平.
- 在体内,线粒延长了生存期,减少了瘤大小,减少了Siglec-10+/TREM2+细胞,增加了CD8+细胞.
结论:
- 用米托克桑对CD24/Siglec-10轴进行向显示了治疗潜力.
- 米托克桑可能调节瘤微环境并增强抗瘤免疫力.
更多相关视频
08:57Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
2.6K
09:37Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
2.2K
相关概念视频
Alterations in Respiration II
1.8K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.8K
Altered States of Awareness
1.1K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.1K
Chromatin Position Affects Gene Expression
24.8K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.8K
What is Gene Expression?
196.6K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.6K
What is Gene Expression?
11.4K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.4K
Alterations in Blood Pressure
2.2K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.2K
