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Updated: Jan 30, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
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PAF15-PCNA的耗尽控制了DNA复制的链特异性控制

Gita Chhetri1, Sugith Babu Badugu1, Narcis-Adrian Petriman1

  • 1Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.

Nature
|January 28, 2026
PubMed
概括

过度的DNA复制原始点火消耗了增殖细胞核抗原 (PCNA) 相关因子15 (PAF15),阻止了DNA合成. 这项研究揭示了PAF15的剂量和链特异性如何调节复制分叉进展和S相检查点控制.

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