固体瘤患者中MASCC得分与发烧性中性质疏松症的演变之间的相关性:一项回顾性研究
Charles-Eric Rivest1,2, Fatim Ezzahra Ben Abderrazik3,4, Marc-Antoine Côté-Marcoux3,5,4
1Centre Hospitalier Universitaire de Sherbrooke (CHUS), 3001 12E Avenue Nord, Sherbrooke, QC, J1H 5H3, Canada. charles-eric.rivest@usherbrooke.ca.
概括
跨国癌症支持护理协会 (MASCC) 评分对于识别具有固体瘤的低风险发烧性中性质不良症 (FN) 患者具有中度的特异性. 虽然它减少了住院负担,但临床判断对于门诊管理至关重要.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 跨国癌症支持护理协会 (MASCC) 评分是评估癌症患者发烧性中性质衰竭 (FN) 风险的标准工具.
- 由于临床表现和结果的潜在差异,它的实用性在患有固体瘤的患者中需要进一步验证.
研究的目的:
- 评估MASCC得分在预测非复杂的临床疗程的准确性,对于患有FN的固体瘤患者.
- 评估MASCC评分在识别符合门诊管理条件的低风险FN患者方面的表现.
主要方法:
- 从2011年到2022年,CHUS进行了一项回顾性队列研究.
- 根据MASCC评分 (低风险≥21,高风险<21) 纳入并分层成年患者,他们接受了固体瘤化疗后的FN二次化疗.
- 主要结局是得分能够预测一个不复杂的过程95%的特异性;二级结局包括ICU入院,死亡率和住院时间.
主要成果:
- 在329名患者中,69%被归类为低风险. 马斯克得分显示灵敏度为83.5%,但预测不复杂的过程的特异性仅为57.3%.
- 与高风险患者相比,低风险患者的ICU入院率 (0.4%对32.7%) 和死亡率 (0.9%对16.8%) 显著降低.
- 符合条件的患者的门诊治疗可以节省486天的住院时间,其中80.7%的患者没有并发症.
结论:
- 由于MASCC评分的适度特异性,它在识别固体瘤FN患者的准确性受到限制,这些患者将保持无并发症.
- 尽管有局限性,但MASCC得分有效降低了低风险患者的住院负担.
- 除了MASCC得分之外,将其他临床参数整合起来,可能会提高这一群体门诊治疗决策的风险分层.
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