功能性训练可以缓解复发性转移性多发性硬化症患者循环中的降低的英多尔-3-乳酸盐水平
Tiffany Wences Chirino1, Frederike Adammek1, Sergen Belen1,2
1Sports Medicine Research Group, Institute for Sport and Sport Science, TU Dortmund University, Dortmund, Germany.
Acta physiologica (Oxford, England)
|January 28, 2026
概括
定期炼和为期10周的多式训练计划显著改善了多发性硬化症患者的英多尔-3-乳酸盐/英多尔-3-酸盐指数. 单次运动会也提高了印-3-乳酸盐水平,这表明神经保护作用有好处.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 托衍生肠道微生物代谢物英多尔 (Indole) 对多发性硬化症 (MS) 中的肠-大脑轴有影响.
- 印度醇-3-乳酸盐 (ILA) 在多发性硬化症患者中降低,并在动物模型中表现出抗炎,复髓化特性.
- ILA/英多尔-3-酸盐 (IAA) 比率 (ILA/IAA) 作为神经保护指数,可通过运动和饮食进行修改.
研究的目的:
- 调查急性和慢性运动对复发性复发性多发性硬化症 (RRMS) 患者血清内醇水平的影响.
- 评估一个为期10周的多模式功能培训计划对ILA/IAA指数的影响.
- 为了评估单次炼对循环中的内醇水平的急性影响.
主要方法:
- 一个随机对照试验的二次分析,涉及31名RRMS患者.
- 血清英多尔度的比较 (用LC-MS/MS测量) 在基线,10周干预后和匹配的健康对照中.
- 通过在训练之前,训练期间和训练结束后立即抽取血液样本来评估急性运动的影响.
主要成果:
- 与健康对照组相比,RRMS患者表现出不同的基线英多尔水平,ILA降低.
- 慢性多模式培训 (10周) 显著提高了ILA/IAA指数.
- 一次急性炼导致ILA和ILA/IAA指数的水平增加.
结论:
- 一个为期10周的多模式功能培训计划改善了RRMS患者的ILA/IAA指数,表明了肠道微生物群的潜在神经保护性转变.
- 急性运动可以迅速增加循环中的ILA水平.
- 运动干预措施对调节肠道微生物群代谢物和支持MS中神经保护有希望.
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