甘酸A调节肠道神经元和肠道平衡在刺激性肠综合征由微生物群感应微生物群感应
Rong-Wei Kou1, Rui-Jing Zhang2, Bing Xia3
1Department of Applied Chemistry, Xi'an University of Technology, Xi'an 710054, Shaanxi, People's Republic of China.
Journal of agricultural and food chemistry
|January 28, 2026
概括
来自Ganoderma lucidum的甘酸A (GAA) 通过调节肠道细菌和肠道神经元来缓解易怒肠综合征 (IBS) 的症状. 这项研究揭示了GAA.
科学领域:
- 胃肠病学和药理学 胃肠病学和药理学
- 微生物学和免疫学
背景情况:
- 刺激性肠综合征 (IBS) 是一种功能性胃肠疾病,其特征是内脏过敏和不运动.
- 甘酸A (GAA) 是来自Ganoderma lucidum的三基,已知其对健康有好处,但其对IBS的影响尚未被探索.
研究的目的:
- 在刺激性肠综合征 (IBS) 的小鼠模型中研究甘酸A (GAA) 的治疗潜力.
- 阐明GAA作用的潜在机制,重点关注肠道微生物群,肠道神经元和肠道平衡.
主要方法:
- 在C57BL/6小鼠中使用Citrobacter rodentium挑战和避免水的压力诱导了IBS类型的表型.
- 给小鼠补充了GAA,并通过测量IBS症状,肠道运动,神经元活动,炎症,屏障完整性和巨细胞活动来评估结果.
- 分析了肠道微生物群的组成,酸盐代谢和酸受体 (AhR) 信号传递. 用抗生素治疗来确认微生物群的依赖性.
主要成果:
- 补充GAA显著缓解了IBS类症状,改善了肠道运动性并减少了内脏过敏.
- GAA使肠道nNOS+和ChAT+神经元正常化,减少结肠炎症,加强上皮质屏障完整性,并使乳腺细胞活动正常化.
- GAA调节了肠道微生物群,通过三甲代谢细菌促进了 indole-3-aldehyde (IAld) 的产生,激活了 AhR 信号. 这些好处被抗生素治疗取消了.
结论:
- 甘酸A (GAA) 在小鼠中显示出针对IBS类症状的显著治疗效果.
- GAA通过微生物群感应机制起作用,影响肠道细菌,托代谢和AhR信号,以恢复肠道平衡.
- 这些发现突出了GAA作为管理IBS和相关胃肠道疾病的潜在营养策略.
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