运动和亚麻油摄入量对肥胖小鼠海马功能之间的相互作用:GPR120的案例
Leandro Kansuke Oharomari1, Camila Venturini Ayres Cunha1, Julia Boro de Lima2
1Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil; Nutritional Genomics and Lipids Research Center (CELN), Limeira, São Paulo, Brazil.
亚麻油和运动在肥胖小鼠中部分降低了焦虑,但没有改善海马体功能. 将omega-3脂肪酸与运动相结合可能不足以获得肥胖症的认知益处.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 肥胖和身体不活动是痴呆症的关键可修改的风险因素.
- 营养和运动对于维持认知功能至关重要.
- 营养素和炼对肥胖中中枢神经系统的协同作用仍未得到充分研究.
研究的目的:
- 为了研究亚麻油 (omega-3脂肪酸来源) 和有氧运动在饮食诱导的肥胖小鼠模型中的海马功能之间的相互作用.
- 在肥胖和干预条件下,探索海马体中欧米茄-3受体GPR120在肥胖和干预条件下的作用.
主要方法:
- 为了诱导肥胖,小鼠被食高脂肪饮食12周.
- 干预措施包括有氧跑步机运动和亚麻油补充剂.
- 评估了肥胖现象型,葡萄糖代谢,焦虑行为和海马GPR120表达.
主要成果:
- 高脂肪饮食导致肥胖,体重增加,脂肪组织和禁食血糖.
- 有氧运动部分减轻了体重增加,但只有与亚麻油相结合,葡萄糖代谢才会改善.
- 肥胖小鼠表现出焦虑行为和海马GPR120增加;联合干预轻微减少了焦虑,但没有改变GPR120或炎症标志物.
结论:
- 肥胖会增加焦虑和海马GPR120,这表明它可能是认知能力下降的潜在目标.
- 四周的麻油和有氧运动组合不足以增强肥胖小鼠的海马功能.
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