来自Ganoderma atrum的多糖化合物延缓衰老,并通过调节Caenorhabditis elegans中的IIS和MAPK通路来增强抗压能力
Jiayan Xie1, Mengni Shu1, Xinyi Chen1
1State Key Laboratory of Food Science and Resources, China-Canada Joint Laboratory of Food Science and Technology (Nanchang), Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University,235 Nanjing East Road, Nanchang 330047, China.
Food research international (Ottawa, Ont.)
|January 29, 2026
概括
来自Ganoderma atrum (PSG) 的多糖在C. elegans中显著延长寿命并改善健康寿命. 这种天然化合物增强了抗压力和抗氧化活性,表明作为促进健康的食补充剂的潜力.
科学领域:
- 老年学是指老年学的学科.
- 菌类学 菌类学是指菌类学.
- 生物化学 生物化学
背景情况:
- 甘菌 (Ganoderma atrum) 是一种以抗氧化,抗炎和抗衰老特性而闻名的药用真菌.
- 多糖是具有潜在健康益处的生物活性化合物.
研究的目的:
- 为了评估Ganoderma atrum多糖 (PSG) 在Caenorhabditis elegans的抗衰老作用.
- 调查PSG对寿命,健康和防御系统的影响.
- 阐明 PSG 抗衰老作用背后的分子机制.
主要方法:
- 在不同度下向C. elegans注射PSG.
- 评估寿命,运动,速率,脂素积累,反应性氧物种 (ROS) 水平,化疗和肠道透性.
- 评估抗压力和抗氧化酶活性.
- 在突变菌株 (DAF-16/FOXO,SKN-1/Nrf-2) 和信号通路 (IIS,MAPK) 中基因表达的分析.
主要成果:
- PSG显著延长了C. elegans的寿命,在400μg/mL时的最佳增加为23.10%.
- 改善的健康指标,包括增强的运动能力,减少脂素积累,以及更好的抗压能力.
- 观察到抗氧化酶活性增加和脂质积累减少.
- 寿命延长取决于DAF-16/FOXO和SKN-1/Nrf-2,这涉及到IIS和MAPK路径.
结论:
- 甘树多糖 (PSG) 在C. elegans中显示出显著的抗衰老潜力.
- PSG改善了多个健康范围的参数,并增强了生物体的防御系统.
- 抗衰老作用通过DAF-16/FOXO和SKN-1/Nrf-2通路进行介导.
- PSG是营养补充剂的有希望的候选者,可以促进健康并对抗与年龄相关的衰退.
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