代谢性疾病和大动脉结石化之间的双向联系:从致病机制到综合多病症管理
Xinyue Wang1,2, Mincheng Yu1,2, Jingzheng Chen1,2
1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Expert opinion on therapeutic targets
|January 29, 2026
概括
大动脉结石性疾病 (CAVD) 缺乏有效的药物治疗方法. 本综述探讨了代谢疾病与大动脉结石化 (AVC) 之间的联系,为新的治疗点提出了"结石化-代谢轴"的建议.
科学领域:
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
- 病理生理学 病理生理学
背景情况:
- 气动脉疾病 (CAVD) 是一个重大的全球健康挑战.
- 目前对CAVD的治疗主要依赖于门置换手术.
- 迫切需要有效的药物治疗来管理CAVD.
研究的目的:
- 系统地审查代谢性疾病与大动脉结石化 (AVC) 之间的流行病学联系.
- 阐明连接代谢障碍和AVC的常见机械路径.
- 引入"化-代谢轴"作为理解CAVD的框架.
主要方法:
- 在PubMed数据库中进行全面的文献搜索,截至2025年12月.
- 专注于研究CAVD,新陈代谢,炎症和化信号的研究.
- 系统评估流行病学关联和机制性途径.
主要成果:
- 代谢性疾病在流行病学上与大动脉结石化 (AVC) 有关.
- 常见的机制性路径,称为"化-代谢轴",将代谢功能障碍与AVC联系起来.
- 这涉及炎症和特定的化信号通路.
结论:
- 未来的CAVD管理应整合早期的多病共同治理.
- 开发针对"化-代谢轴"内的途径的向药物至关重要.
- 药物治疗有望超越目前对手术门置换的依赖.
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