基线D-二分体作为免疫检查点抑制剂在癌症中有效性的预测指标
1Department of Basic Medicine, Anqing Medical College, Anqing, Anhui, China.
Annals of medicine
|January 29, 2026
概括
癌症患者的D-二聚物水平升高预测免疫检查点抑制剂 (ICI) 的治疗结果较差. 这种易于获得的生物标志物可以帮助识别不太可能从免疫治疗中受益的患者,指导治疗决策.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 生物标志物发现发现
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗,但只对一小部分患者有益.
- 预测ICI疗效的生物标志物对于优化治疗策略至关重要.
- 凝血的标志物D-二聚合物在ICI治疗患者中具有不清楚的预测价值.
研究的目的:
- 系统地审查和元分析基线D-二分体对接受ICI的癌症患者的预测结果的预测值.
- 评估D-二聚物水平与整体存活率,无进展存活率和反应率之间的关联.
主要方法:
- 对10项涉及1217名患者的回顾性研究进行了系统审查和元分析.
- 数据提取和质量评估是独立进行的.
- 计算了聚合的危险比率和赔率比率,并进行了灵敏度和子组分析.
主要成果:
- 基线D-二次数升高显著相关于较差的整体存活率 (HR=1.95) 和无进展存活率 (HR=2.03).
- 较高的D-二次体水平与较低的客观反应率 (OR=0.42) 和疾病控制率 (OR=0.18) 相关.
- 关联在各种瘤类型,治疗方法和D-二次元值中保持强.
结论:
- 基线D-二分体是一种具有成本效益的生物标志物,可预测ICI治疗患者的劣质结果.
- 将D-二聚物纳入临床实践可能会改善患者分层和治疗选择.
- 需要进一步的前性研究来验证D-二分体值,以优化免疫治疗.
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