S2-PepAnalyst:用于预测植物小信号的网络工具
Kelly L Vomo-Donfack1,2, Mariem Abaach3, Ana M Luna2
1Université Sorbonne Paris Nord, LAGA, CNRS, UMR 7539, Laboratoire D'excellence Infibrex, Villetaneuse, France.
Plant biotechnology journal
|January 29, 2026
概括
研究人员开发了S2-PepAnalyst,这是一种机器学习工具,用于识别植物中的小信号 (SSP). 这种工具有助于理解植物细胞的沟通,改善作物.
科学领域:
- 植物生物学 植物生物学
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 小信号 (SSP) 对于植物细胞的沟通,调节发育和应激反应至关重要.
- 鉴定新型SSP是困难的,因为它们的小尺寸,序列变化,和短暂的表达.
研究的目的:
- 开发一个计算工具,S2-PepAnalyst,用于高效地预测和分类工厂SSP.
- 克服植物基因组中识别和表征小信号的局限性.
主要方法:
- 开发了S2-PepAnalyst,这是一个使用机器学习,蛋白质语言模型和几何拓特征的Web工具.
- 综合工厂特定数据集和SSP分析的先进计算方法.
- 验证了该工具与实验证实的对比.
主要成果:
- 在识别小信号时,S2-PepAnalyst实现了99.5%的预测准确度.
- 该工具成功地将类归类为已知的家族 (例如,CLE,RALF) 并确定了非正规的SSP.
- 在各种植物物种中表现出强大的性能,包括模型和作物植物.
结论:
- S2-PepAnalyst是一个强大的,自由可用的资源,用于探索植物小信号.
- 促进植物细胞信号发送的发现,并有助于作物改进战略.
- 授权研究人员系统地调查基本上尚未开发的SSP曲目.
相关概念视频
Cell Signaling in Plants
6.2K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
6.2K
Peptide Bonds
82.8K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
82.8K
Plant Hormones
27.5K
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
27.5K
Predicting Molecular Geometry
45.7K
VSEPR Theory for Determination of Electron Pair Geometries
45.7K
Bacterial Signaling
40.6K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.6K
Yeast Signaling
17.3K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
17.3K


