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相关概念视频

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Redox Titration: Other Oxidizing and Reducing Agents01:26

Redox Titration: Other Oxidizing and Reducing Agents

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Besides iodine, other oxidizing or reducing agents can serve as titrants in redox titrations. Common oxidizing titrants include KMnO4, cerium(IV), and K2Cr2O7. The choice of oxidizing titrants depends on factors like stability, cost, analyte strength, and reaction rate between the analyte and titrant. KMnO4 is a strong oxidizing titrant that reduces from Mn(VII) to Mn(II) in a highly acidic solution, simultaneously oxidizing the analyte to a higher oxidation state. In this case, KMnO4 acts as a...
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Electrolyte and Nonelectrolyte Solutions02:21

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Substances that undergo either a physical or a chemical change in solution to yield ions that can conduct electricity are called electrolytes. If a substance yields ions in solution, that is, if the compound undergoes 100% dissociation, then the substance is a strong electrolyte. Complete dissociation is indicated by a single forward arrow. For example, water-soluble ionic compounds like sodium chloride dissociate into sodium cations and chloride anions in aqueous solution.
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Electrolytes: van't Hoff Factor03:08

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Colligative Properties of Electrolytes
The colligative properties of a solution depend only on the number, not on the identity, of solute species dissolved. The concentration terms in the equations for various colligative properties (freezing point depression, boiling point elevation, osmotic pressure) pertain to all solute species present in the solution. Nonelectrolytes dissolve physically without dissociation or any other accompanying process. Each molecule that dissolves yields one...
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In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
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超敏感的微RNA检测,结合了减少的氧化石墨烯电解质门式晶体管和机器学习.

Ana Vitória Ferreira Deleigo1,2, Gabrielle Coelho Lelis1,3, Maria Luisa Braunger1

  • 1Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.

Small (Weinheim an der Bergstrasse, Germany)
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PubMed
概括
此摘要是机器生成的。

这项研究介绍了一种用于检测微RNA (miRNA) 的新型生物传感器,这些生物传感器是疾病的关键生物标志物. 这种先进的系统为潜在的便携式诊断应用提供了高度敏感和选择性的检测.

关键词:
两维材料是二维材料.电解质门通晶体管的电解质门通晶体管.机器学习是机器学习.这是一个微型RNA.临床医疗中心的检测.

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科学领域:

  • 生物分子工程 生物分子工程
  • 纳米技术 纳米技术
  • 机器学习 机器学习

背景情况:

  • 微RNAs (miRNAs) 是疾病诊断的重要生物标志物.
  • 传统的检测方法,如RT-PCR是复杂的,不适合便携式诊断.
  • miR-34家族与癌症和神经系统疾病有关.

研究的目的:

  • 开发一个超敏感和选择性的生物传感器用于miRNA检测.
  • 为了实现便携式分子诊断.
  • 针对miR-34家族进行疾病关联研究.

主要方法:

  • 整合了DNA功能化的减少氧化石墨烯 (rGO) 和电解质导入晶体管 (EGT).
  • 利用机器学习 (ML) 来分析EGT转移曲线的数据.
  • 开发了一种生物传感器,可以从不匹配的miRNA序列中分辨出完美匹配的.

主要成果:

  • 达到了0.098 amol L-1的超低检测极限.
  • 证明了高选择性和广泛的动态范围 (0.1-1000 amol L-1).
  • ML使得从高维数据中有效地提取特征.

结论:

  • 开发的生物传感器推进了用于miRNA检测的临床技术.
  • 这个平台显示出高度敏感和选择性的便携式分子诊断的巨大潜力.
  • 整合rGO,EGT和ML为未来的诊断工具提供了一个有希望的方法.