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Updated: Jan 30, 2026

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
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向SP1/ACSL4轴减轻了trastuzumab诱导心脏毒性的铁亡

Qiyuan Hu1, Bincheng Zhong2, Yajie Zheng3

  • 1Department of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Drug and chemical toxicology
|January 29, 2026
PubMed
概括

特拉斯图祖马布治疗通过ferroptosis引起心脏损伤,这是一种涉及脂质过氧化的过程. 抑制SP1转录因子可以预防这种心脏毒性,提高癌症治疗的安全性.

关键词:
在 ACSL4 中使用.心脏有毒性 - 心脏有毒性SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1 SP1这就是Trastuzumab.铁性化 (ferroptosis) 是一种

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